Welcome to the Henrickson Lab

Immune dysfunction in Allergic and Immunologic Disease

Taking on T cell dysfunction in chronic inflammation and primary immune deficiency by finding questions at the bedside and bringing them to the bench and back.

 

Our research

We focus on understanding the role of T cell dysfunction in chronic allergic and inflammatory disease, including asthma and obesity, as well as rare, monogenic primary immunodeficiency. To this end, the team uses complementary approaches in humans and mice, leveraging detailed immunophenotyping and metabolic characterization of immune dysfunction in patients to identify mechanistic hypotheses to test in mouse models and human cells in vitro.

Our Team

Recent News

Our lab recently recieved a grant from the Additional Ventures Single Ventricle Research Fund (SVRF) for a new study investigating the impact of early life hypoxia in single ventricle congenital heart disease on the immune system.

List of Additional Ventures 2024 SVRF Recipients

August 2024

Please see our recent preprint in MedRxiv on the role of STAT signaling in severe pediatric sepsis:

Dysregulated STAT3 signaling and T cell immunometabolic dysfunction define a targetable, high mortality subphenotype of critically ill children

Congratulations to Brad Lindell, MD and his team for their hard work on this project!

June 2024